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They create OS (high level of hydrogen peroxide, and decrease the level of catalase enzyme and glutathione peroxidase enzyme) (Agrawal et al., 2004), which leads to ER imbalance (Guan et al., 2015), caused by damage to poly unsaturated fatty acids of the cell membrane and break the disulfide bonds in proteins, that cause an accumulation of unfolded proteins in the ER

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PROEX 165.0/20) and carried out in compliance with the guidelines in RD53/2013 (Spain)

Moreover, skeletal muscle injury models have suggested a beneficial effect not only for disturbances that occur as a result of direct trauma but also for systemic insults including hyperkalamia and hypermagnesia

doi:10.1016/S0065-2113(08)60504-0

Weight loss is the go-to method of treating NASH